Probable transcription factor. Plays a critical role in the control of immune response.
Involvement in disease
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.
Immune dysregulation polyendocrinopathy enteropathy X linked antibody
Immunodeficiency polyendocrinopathy enteropathy X linked antibody
Western blot - Anti-FOXP3 antibody [mAbcam 22510] (HRP) (ab22831)
All lanes : Anti-FOXP3 antibody [mAbcam 22510] (HRP) (ab22831) at 1/1000 dilution
Lane 1 : HEK 293 cells overexpressing human FOXP3 Lane 2 : HEK 293 cells overexpressing human FOXP3 with Human FOXP3 peptide (ab16809) at 1 µg/ml
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 50 kDa Observed band size: 50 kDa
Exposure time: 3 minutes
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP3 antibody [mAbcam 22510] (HRP) (ab22831)This image is courtesy of an Abreview submitted by Antibody Solutions Ltd.
ab22831 staining FOXP3 in human tonsil tissue section by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Tissue underwent fixation in formaldehyde, heat mediated antigen retrieval in buffer and blocked (5 minutes/peroxidase block then 10 minutes/protein block) for 15 minutes at 20°C. The primary antibody was diluted, 1/50 and incubated with sample for 45 minutes at 20°C.