Overview

  • Product name
    Anti-FOXP3 antibody [SP97]
    See all FOXP3 primary antibodies
  • Description
    Rabbit monoclonal [SP97] to FOXP3
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to C-terminus of Human FOXP3.

  • Positive control
    • Human Tonsil
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab99963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Boil tissue section in 10mM Citrate, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Target

  • Function
    Probable transcription factor. Plays a critical role in the control of immune response.
  • Involvement in disease
    Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.
  • Sequence similarities
    Contains 1 C2H2-type zinc finger.
    Contains 1 fork-head DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AIID antibody
    • DIETER antibody
    • Forkhead box P3 antibody
    • Forkhead box protein P3 antibody
    • FOXP3 antibody
    • FOXP3_HUMAN antibody
    • FOXP3delta7 antibody
    • Immune dysregulation polyendocrinopathy enteropathy X linked antibody
    • Immunodeficiency polyendocrinopathy enteropathy X linked antibody
    • IPEX antibody
    • JM2 antibody
    • MGC141961 antibody
    • MGC141963 antibody
    • OTTHUMP00000025832 antibody
    • OTTHUMP00000025833 antibody
    • OTTHUMP00000226737 antibody
    • PIDX antibody
    • Scurfin antibody
    • XPID antibody
    see all

Images

  • Immunohistochemical analysis of Human Tonsil tissue labelling FOXP3 with ab99963.

References

This product has been referenced in:
  • Märkl B  et al. The role of lymph node size and FOXP3+ regulatory T cells in node-negative colon cancer. J Clin Pathol 70:443-447 (2017). Read more (PubMed: 27879345) »
  • Stenström B  et al. Helicobacter pylori overcomes natural immunity in repeated infections. Clin Case Rep 4:1026-1033 (2016). Read more (PubMed: 27830066) »

See all 3 Publications for this product

Customer reviews and Q&As

For IHC-P staining with product ab99963, Human Tonsil Samples were formalin fixed.

Our full IHC-P fixation protocol can be found here: IHC Fixation Protocol.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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