FOXR1 is a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix turn helix proteins with a core DNA binding domain of approximately 110 amino acids. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas.
Petit FG et al. Combining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human. Biol Reprod92:71 (2015).
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