Overview

  • Product name
    Anti-FRAT1 antibody [EPR3900]
    See all FRAT1 primary antibodies
  • Description
    Rabbit monoclonal [EPR3900] to FRAT1
  • Tested applications
    Suitable for: WB, IP, ICC, Flow Cytmore details
    Unsuitable for: IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) (internal sequence)

  • Positive control
    • HeLa and MCF7 cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab108405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 29 kDa.
IP 1/10 - 1/100.
ICC 1/100 - 1/250.
Flow Cyt 1/500 - 1/1000.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

  • Application notes
    Is unsuitable for IHC-P.
  • Target

    • Relevance
      The protein encoded by the FRAT1 gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and also positively regulates the Wnt signaling pathway. It may play a role in tumor progression and in lymphomagenesis.
    • Cellular localization
      Cytoplasmic
    • Database links
    • Alternative names
      • FRAT 1 antibody
      • frequently rearranged in advanced T cell lymphomas antibody
      • Frequently rearranged in advanced T-cell lymphomas antibody
      • GSK 3 binding protein FRAT1 antibody
      • proto oncogene FRAT1 antibody
      see all

    Images

    • All lanes : Anti-FRAT1 antibody [EPR3900] (ab108405) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 29 kDa

    References

    This product has been referenced in:
    • Werner TV  et al. MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2. Aging (Albany NY) 9:932-954 (2017). WB . Read more (PubMed: 28340489) »
    • Zhu K  et al. FRAT1 expression regulates proliferation in colon cancer cells. Oncol Lett 12:4761-4766 (2016). Read more (PubMed: 28101222) »

    See all 5 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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