Overview

  • Product name
  • Description
    Rabbit polyclonal to FREM1
  • Specificity
    ab105360 is predicted to not crossreact with other FRAS members. Multiple isoforms are known to exist.
  • Tested applications
    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A 15 amino acid peptide near the C terminus of Human FREM1 (NP_659403).

  • Positive control
    • K562 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab105360 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 244 for isoform 1 , for isoform 2, 80 kDa.
ICC Use a concentration of 20 µg/ml.

Target

  • Function
    Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.
  • Involvement in disease
    Defects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR) [MIM:608980]. A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations.
  • Sequence similarities
    Belongs to the FRAS1 family.
    Contains 1 C-type lectin domain.
    Contains 1 Calx-beta domain.
    Contains 12 CSPG (NG2) repeats.
  • Domain
    The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix > basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles.
  • Information by UniProt
  • Database links
  • Alternative names
    • BC037594 antibody
    • BNAR antibody
    • C9orf143 antibody
    • C9orf145 antibody
    • C9orf154 antibody
    • D430009N09 antibody
    • D630008K06 antibody
    • FLJ25461 antibody
    • FRAS1-related extracellular matrix protein 1 antibody
    • FREM 1 antibody
    • FREM1 antibody
    • FREM1_HUMAN antibody
    • Heb antibody
    • MOTA antibody
    • Protein QBRICK antibody
    • QBRICK antibody
    • RGD1306981 antibody
    • RP11-265B7.2 antibody
    • RP23-410K19.1 antibody
    • TILRR antibody
    see all

Anti-FREM1 antibody images

  • Immunofluorescence of FREM1 in K562 cells with ab105360 at 20 ug/mL.

  • Lane 1 : Anti-FREM1 antibody (ab105360) at 1 µg/ml
    Lane 2 : Anti-FREM1 antibody (ab105360) at 0.5 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 244 for isoform 1 , for isoform 2, 80 kDa
  • Immunocytochemistry of FREM1 in K562 cells with ab105360 at 20 µg/ml.

References for Anti-FREM1 antibody (ab105360)

ab105360 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab105360.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up