Overview

  • Product name
  • Description
    Rabbit polyclonal to FREM1
  • Specificity
    ab105360 is predicted to not crossreact with other FRAS members. Multiple isoforms are known to exist.
  • Tested applications
    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A 15 amino acid peptide near the C terminus of Human FREM1 (NP_659403).

  • Positive control
    • K562 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab105360 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 244 for isoform 1 , for isoform 2, 80 kDa.
ICC Use a concentration of 20 µg/ml.

Target

  • Function
    Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.
  • Involvement in disease
    Defects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR) [MIM:608980]. A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations.
  • Sequence similarities
    Belongs to the FRAS1 family.
    Contains 1 C-type lectin domain.
    Contains 1 Calx-beta domain.
    Contains 12 CSPG (NG2) repeats.
  • Domain
    The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix > basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles.
  • Information by UniProt
  • Database links
  • Alternative names
    • BC037594 antibody
    • BNAR antibody
    • C9orf143 antibody
    • C9orf145 antibody
    • C9orf154 antibody
    • D430009N09 antibody
    • D630008K06 antibody
    • FLJ25461 antibody
    • FRAS1-related extracellular matrix protein 1 antibody
    • FREM 1 antibody
    • FREM1 antibody
    • FREM1_HUMAN antibody
    • Heb antibody
    • MOTA antibody
    • Protein QBRICK antibody
    • QBRICK antibody
    • RGD1306981 antibody
    • RP11-265B7.2 antibody
    • RP23-410K19.1 antibody
    • TILRR antibody
    see all

Images

  • Immunofluorescence of FREM1 in K562 cells with ab105360 at 20 ug/mL.

  • Lane 1 : Anti-FREM1 antibody (ab105360) at 1 µg/ml
    Lane 2 : Anti-FREM1 antibody (ab105360) at 0.5 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 244 for isoform 1 , for isoform 2, 80 kDa
  • Immunocytochemistry of FREM1 in K562 cells with ab105360 at 20 µg/ml.

References

ab105360 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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