Overview

  • Product nameAnti-FREM1 antibody
    See all FREM1 primary antibodies
  • Description
    Rabbit polyclonal to FREM1
  • Tested applicationsSuitable for: WB, ELISA, IHC-P, ICCmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, from the C terminus of Human FREM1.

  • Positive control
    • Human tonsil tissue.
  • General notesStable for one year at 4°C.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab117566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 244 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml.
ICC Use at an assay dependent concentration.

Target

  • FunctionExtracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.
  • Involvement in diseaseDefects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR) [MIM:608980]. A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations.
  • Sequence similaritiesBelongs to the FRAS1 family.
    Contains 1 C-type lectin domain.
    Contains 1 Calx-beta domain.
    Contains 12 CSPG (NG2) repeats.
  • DomainThe Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding.
  • Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles.
  • Information by UniProt
  • Database links
  • Alternative names
    • BC037594 antibody
    • BNAR antibody
    • C9orf143 antibody
    • C9orf145 antibody
    • C9orf154 antibody
    • D430009N09 antibody
    • D630008K06 antibody
    • FLJ25461 antibody
    • FRAS1-related extracellular matrix protein 1 antibody
    • FREM 1 antibody
    • FREM1 antibody
    • FREM1_HUMAN antibody
    • Heb antibody
    • MOTA antibody
    • Protein QBRICK antibody
    • QBRICK antibody
    • RGD1306981 antibody
    • RP11-265B7.2 antibody
    • RP23-410K19.1 antibody
    • TILRR antibody
    see all

Anti-FREM1 antibody images

  • ab117566, at 10 µg/ml, staining FREM1 in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.

References for Anti-FREM1 antibody (ab117566)

ab117566 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab117566.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"