Overview

  • Product name
  • Description
    Rabbit polyclonal to FREM2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ELISA, IHC-P, ICCmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to 19 internal sequence amino acids of Human FREM2.

  • Positive control
    • Human Breast and Human Kidney tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab117612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 351 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.
ICC Use at an assay dependent concentration.

Target

  • Function
    Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.
  • Involvement in disease
    Defects in FREM2 are a cause of Fraser syndrome (FRASS) [MIM:219000]. Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects.
  • Sequence similarities
    Belongs to the FRAS1 family.
    Contains 5 Calx-beta domains.
    Contains 12 CSPG (NG2) repeats.
  • Domain
    The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp781I048 antibody
    • ECM3 homolog antibody
    • FRAS1-related extracellular matrix protein 2 antibody
    • FREM 2 antibody
    • Frem2 antibody
    • FREM2_HUMAN antibody
    • KIAA1074 antibody
    see all

Images

  • ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human breast tissue by Immunohistochemistry.
  • ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry.

References

ab117612 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab117612.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up