Overview

  • Product nameAnti-FREM2 antibody
    See all FREM2 primary antibodies
  • Description
    Rabbit polyclonal to FREM2
  • Tested applicationsSuitable for: WB, ELISA, IHC-P, ICCmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to 19 internal sequence amino acids of Human FREM2.

  • Positive control
    • Human Breast and Human Kidney tissues.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab117612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 351 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.
ICC Use at an assay dependent concentration.

Target

  • FunctionExtracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.
  • Involvement in diseaseDefects in FREM2 are a cause of Fraser syndrome (FRASS) [MIM:219000]. Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects.
  • Sequence similaritiesBelongs to the FRAS1 family.
    Contains 5 Calx-beta domains.
    Contains 12 CSPG (NG2) repeats.
  • DomainThe Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp781I048 antibody
    • ECM3 homolog antibody
    • FRAS1-related extracellular matrix protein 2 antibody
    • FREM 2 antibody
    • Frem2 antibody
    • FREM2_HUMAN antibody
    • KIAA1074 antibody
    see all

Anti-FREM2 antibody images

  • ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human breast tissue by Immunohistochemistry.
  • ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry.

References for Anti-FREM2 antibody (ab117612)

ab117612 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab117612.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"