Anti-FREM2 antibody (ab117612)
Key features and details
- Rabbit polyclonal to FREM2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-FREM2 antibody -
Description
Rabbit polyclonal to FREM2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide conjugated to KLH, corresponding to 19 internal sequence amino acids of Human FREM2.
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Positive control
- Human Breast and Human Kidney tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab117612 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 µg/ml.
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Notes |
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IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion. -
Involvement in disease
Defects in FREM2 are a cause of Fraser syndrome (FRASS) [MIM:219000]. Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects. -
Sequence similarities
Belongs to the FRAS1 family.
Contains 5 Calx-beta domains.
Contains 12 CSPG (NG2) repeats. -
Domain
The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 341640 Human
- Entrez Gene: 242022 Mouse
- Omim: 608945 Human
- SwissProt: Q5SZK8 Human
- SwissProt: Q6NVD0 Mouse
- Unigene: 253994 Human
- Unigene: 38378 Mouse
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Alternative names
- DKFZp781I048 antibody
- ECM3 homolog antibody
- FRAS1-related extracellular matrix protein 2 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab117612 has not yet been referenced specifically in any publications.