Overview

  • Product name
  • Description
    Rabbit polyclonal to Frequenin
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Chicken, Cow, Human, Xenopus laevis, Drosophila melanogaster
  • Immunogen

    Synthetic peptide corresponding to Rat Frequenin aa 161-190.
    Sequence:

    DGKLTLQEFQEGSKADPSIVQALSLYDGLV

  • Positive control
    • Rat brain extract.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Primary antibody notes
    The neuronal calcium sensor (NCS) proteins are bind calcium through EF-hand motifs and are predominantly expressed in neurons. Photoreceptor cells express type A sensors and include the proteins recoverin, S-modulin, and visinin. Type B receptors are expressed in neurons and include NCS1 and the Drosophila homolog frequenin, and VILIP. NCS1 has been shown to regulate neurosecretion in a calcium-dependent manner, potentiates nitric oxide synthase activity, and can activate calcineurin and 3'-5' nucleotide phosphodiesterase.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab5807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 20 kDa (predicted molecular weight: 25 kDa).

Target

  • Function
    Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
  • Sequence similarities
    Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • Cellular localization
    Golgi apparatus > Golgi stack membrane. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cytoplasm > perinuclear region. Cell membrane. Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
  • Information by UniProt
  • Database links
  • Alternative names
    • Flup antibody
    • Freq antibody
    • frequenin (Drosophila) homolog antibody
    • Frequenin homolog antibody
    • Frequenin-like protein antibody
    • Frequenin-like ubiquitous protein antibody
    • NCS-1 antibody
    • ncs1 antibody
    • NCS1_HUMAN antibody
    • Neuronal calcium sensor 1 antibody
    see all

References

ab5807 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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