Overview

  • Product nameAnti-Frizzled 6 antibody
    See all Frizzled 6 primary antibodies
  • Description
    Rabbit polyclonal to Frizzled 6
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region between amino acids 656-706 of Human Frizzled 6 (NP_003497.2)

  • Positive control
    • HeLa whole cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: Tris citrate/phosphate buffer, pH 7-8
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab105192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use a concentration of 2 - 5 µg/ml.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionReceptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.
    • Tissue specificityDetected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
    • Involvement in diseaseNail disorder, non-syndromic congenital, 10
      Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.
    • Sequence similaritiesBelongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • DomainLys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • Post-translational
      modifications
      Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
    • Cellular localizationMembrane. Cell membrane. Cell surface. Apical cell membrane. Cytoplasmic vesicle membrane. Colocalizes with FZD3 at the apical face of cells (By similarity).
    • Information by UniProt
    • Database links
    • Alternative names
      • Frizzled 6 seven transmembrane spanning receptor antibody
      • Frizzled drosophila homolog of 6 antibody
      • Frizzled family receptor 6 antibody
      • Frizzled homolog 6 (Drosophila) antibody
      • Frizzled homolog 6 antibody
      • Frizzled-6 antibody
      • Frizzled6 antibody
      • Fz 6 antibody
      • Fz-6 antibody
      • Fz6 antibody
      • FZD 6 antibody
      • Fzd6 antibody
      • FZD6_HUMAN antibody
      • Hfz 6 antibody
      • hFz6 antibody
      • NDNC10 antibody
      see all

    Anti-Frizzled 6 antibody images

    • ab105192 at 0.4 µg/ml staining Frizzled 6 in HeLa whole cell lysate immunoprecipitated using ab105192 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence. Exposure time: 3 seconds

    References for Anti-Frizzled 6 antibody (ab105192)

    ab105192 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"