Overview

  • Product name
  • Description
    Rabbit polyclonal to Frizzled 7
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH from the C terminal region of Human Frizzled 7

  • Positive control
    • Human Heart tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab115214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 15 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
  • Tissue specificity
    High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
  • Sequence similarities
    Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • Domain
    Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Frizzled 7, seven transmembrane spanning receptor antibody
    • frizzled class receptor 7 antibody
    • Frizzled drosophila homolog of 7 antibody
    • Frizzled family receptor 7 antibody
    • Frizzled homolog 7 antibody
    • Frizzled-7 antibody
    • Frizzled7 antibody
    • Fz 7 antibody
    • Fz-7 antibody
    • Fz7 antibody
    • FZD 7 antibody
    • FZD7 antibody
    • FZD7_HUMAN antibody
    • FzE 3 antibody
    • FzE3 antibody
    • hFz 7 antibody
    • hFz7 antibody
    • Homolog of Drosophila Frizzled 7 antibody
    • OTTHUMP00000163742 antibody
    see all

Images

  • Human heart (formalin fixed, paraffin embedded) stained with ab115214 at 15 ug/ml followed by biotinylated goat anti Rabbit IgG secondary antibody, alkaline phosphatase streptavidin and chromogen.

References

ab115214 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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