Overview

  • Product name
    Anti-Frizzled homolog 1 antibody
    See all Frizzled homolog 1 primary antibodies
  • Description
    Rabbit polyclonal to Frizzled homolog 1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 113-372 of Human Frizzled homolog 1 (Q9UP38).

  • Positive control
    • Raji whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab126262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 71 kDa.

Target

  • Function
    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
  • Tissue specificity
    Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.
  • Sequence similarities
    Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • Domain
    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • Cellular localization
    Membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Chfz-1 antibody
    • Dfrizzled-1 antibody
    • DKFZp564G072 antibody
    • FLJ95923 antibody
    • Frizzled 1 antibody
    • Frizzled homolog 1 (Drosophila) antibody
    • Frizzled homolog 1 antibody
    • Frizzled-1 antibody
    • Fz receptor 1 antibody
    • Fz-1 antibody
    • Fz1 antibody
    • FZD1 antibody
    • FZD1_HUMAN antibody
    • FzE1 antibody
    • hFz1 antibody
    • Rfz1 antibody
    • Wnt receptor antibody
    • Xfrizzled-1 antibody
    see all

Images

  • Anti-Frizzled homolog 1 antibody (ab126262) at 1/500 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 71 kDa

References

ab126262 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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