Anti-Fructose 6 Phosphate Kinase (phospho S483) antibody (ab59378)

Overview

  • Product nameAnti-Fructose 6 Phosphate Kinase (phospho S483) antibody
    See all Fructose 6 Phosphate Kinase primary antibodies
  • Description
    Rabbit polyclonal to Fructose 6 Phosphate Kinase (phospho S483)
  • SpecificityDetects endogenous levels of Fructose 6 Phosphate Kinase only when phosphorylated at serine 483.
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from Human Fructose 6 Phosphate Kinase around the phosphorylation site of serine 483 (N-Y-SP-V-G).

  • Positive control
    • Human colon carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab59378 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/40000.
IHC-P Use at an assay dependent concentration.

Target

  • PathwayCarbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
  • Involvement in diseaseDefects in PFKM are the cause of glycogen storage disease type 7 (GSD7) [MIM:232800]; also known as Tarui disease. GSD7 is an autosomal recessive disorder characterized by exercise intolerance with associated nausea and vomiting. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise. Most patients obtain a "second wind" when the onset of exercise is followed by a brief rest period. In time patients adjust their activity level and are well compensated.
  • Sequence similaritiesBelongs to the phosphofructokinase family. Two domains subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • 6 Phosphofructokinase Muscle Type antibody
    • 6-phosphofructokinase antibody
    • 6-phosphofructokinase muscle type antibody
    • EC 2.7.1.1 antibody
    • EC 2.7.1.11 antibody
    • GSD7 antibody
    • K6PF_HUMAN antibody
    • MGC8699 antibody
    • muscle type antibody
    • PFK, muscle type antibody
    • PFK-A antibody
    • PFKA antibody
    • PFKL antibody
    • PFKM antibody
    • PFKP antibody
    • PFKX antibody
    • Phosphofructo 1 Kinase Isozyme A antibody
    • Phosphofructo-1-kinase isozyme A antibody
    • Phosphofructokinase 1 antibody
    • Phosphofructokinase M antibody
    • Phosphofructokinase, muscle antibody
    • Phosphofructokinase, muscle type antibody
    • Phosphofructokinase, polypeptide X antibody
    • Phosphofructokinase-M antibody
    • Phosphohexokinase antibody
    see all

Anti-Fructose 6 Phosphate Kinase (phospho S483) antibody images

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using ab59378 at a 1/50-1/100 dilution.

    Left image: untreated.

    Right image: treated with phosphopeptide.

References for Anti-Fructose 6 Phosphate Kinase (phospho S483) antibody (ab59378)

ab59378 has not yet been referenced specifically in any publications.

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