Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.
Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin.
Involvement in disease
A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein.
ALL1-fused gene from chromosome 4p12 protein antibody
FRY like antibody
Furry homolog like (Drosophila) antibody
Furry homolog like antibody
Furry like antibody
Protein furry homolog-like antibody
Western blot - FRYL antibody (ab95011)
All lanes : Anti-FRYL antibody (ab95011) at 0.4 µg/ml
Lane 1 : HeLa whole cell lysate at 50 µg Lane 2 : HeLa whole cell lysate at 15 µg Lane 3 : HeLa whole cell lysate at 5 µg Lane 4 : 293T whole cell lysate at 50 µg
Developed using the ECL technique
Predicted band size : 340 kDa
Exposure time : 3 minutes
Immunoprecipitation - FRYL antibody (ab95011)
ab95011, at 1 µg/ml, detecting FRYL in HeLa whole cell lysate by WB following IP.
Lane 1: IP with an antibody which recognizes an upstream epitope of FRYL
Lane 2: ab95011 at 3 µg/mg of lysate
Lane 3: Control IgG.
In each case, 1 mg of lysate was used for IP and 20% of the IP was loaded.
Detection: Chemiluminescence with an exposure time of 10 seconds