SpecificityReacts with the beta 2 epitope of the beta subunit. Not cross-reactive with human thyroid stimulating hormone, human luteinising hormone, human chorionic gonadotrophin, alpha human chorionic gonadotrophin and alpha human follicle stimulating hormone.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesIHC-P: 1/25 - 1/50. Trypsin digestion of paraffin sections is recommended.
IHC-Fr: 1/25 - 1/50.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceFollicle stimulating hormone (FSH) is a glycoprotein hormone of 35kD which is involved in the maturation of ovarian follicles and stimulation of estrogen secretion. In males, FSH stimulates the secretion of testosterone. It is a heterodimer with an alpha chain shared by thyrotropin, lutropin, follitropin and gonadotropin, and a unique beta chain. It is expressed in gonadotropic cells of the pituitary. FSH is used in the treatment of infertility in women with proven hypopituitarism and in superovulation treatment for assisted conception. In men it is used for the stimulation of spermatogenesis.