This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

Applications

  • Application notesThis antibody gave a positive result in ELISA against the immunizing peptide (ab66734).
    Not yet tested in other applications.
  • Target

    • FunctionIsoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
    • Tissue specificityExpressed in a wide range of tissues.
    • Involvement in diseaseNote=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
    • Sequence similaritiesContains 2 follistatin-like domains.
      Contains 2 Kazal-like domains.
      Contains 1 TB (TGF-beta binding) domain.
    • Cellular localizationSecreted and Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLRG antibody
      • follistatin-like 3 antibody
      • follistatin-like 3 glycoprotein antibody
      • Follistatin-like protein 3 antibody
      • Follistatin-related gene protein antibody
      • Follistatin-related protein 3 antibody
      • FSRP antibody
      • Fstl3 antibody
      • FSTL3_HUMAN antibody
      see all

    References for Anti-FSTL3 antibody (ab65202)

    ab65202 has not yet been referenced specifically in any publications.

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