Anti-FSTL3 antibody [RM0080-7D11] (ab86055)

Overview

  • Product nameAnti-FSTL3 antibody [RM0080-7D11]
    See all FSTL3 primary antibodies
  • Description
    Rat monoclonal [RM0080-7D11] to FSTL3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse recombinant FSTL3.

Properties

Applications

Our Abpromise guarantee covers the use of ab86055 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 28 kDa.

Target

  • FunctionIsoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
  • Tissue specificityExpressed in a wide range of tissues.
  • Involvement in diseaseNote=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
  • Sequence similaritiesContains 2 follistatin-like domains.
    Contains 2 Kazal-like domains.
    Contains 1 TB (TGF-beta binding) domain.
  • Cellular localizationSecreted and Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLRG antibody
    • follistatin-like 3 antibody
    • follistatin-like 3 glycoprotein antibody
    • Follistatin-like protein 3 antibody
    • Follistatin-related gene protein antibody
    • Follistatin-related protein 3 antibody
    • FSRP antibody
    • Fstl3 antibody
    • FSTL3_HUMAN antibody
    see all

References for Anti-FSTL3 antibody [RM0080-7D11] (ab86055)

ab86055 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry.

I heard back from the lab that the western was performed using mouse recombination protein, which gave a size at around 36 kDa in Western. Unfortunately we do not have the western image though.


I ho...

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