Anti-FSTL3 antibody [RM0080-7D11] (ab86055)

Overview

  • Product name
    Anti-FSTL3 antibody [RM0080-7D11]
    See all FSTL3 primary antibodies
  • Description
    Rat monoclonal [RM0080-7D11] to FSTL3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse recombinant FSTL3.

Properties

Applications

Our Abpromise guarantee covers the use of ab86055 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 28 kDa.

Target

  • Function
    Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
  • Tissue specificity
    Expressed in a wide range of tissues.
  • Involvement in disease
    Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
  • Sequence similarities
    Contains 2 follistatin-like domains.
    Contains 2 Kazal-like domains.
    Contains 1 TB (TGF-beta binding) domain.
  • Cellular localization
    Secreted and Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLRG antibody
    • follistatin-like 3 antibody
    • follistatin-like 3 glycoprotein antibody
    • Follistatin-like protein 3 antibody
    • Follistatin-related gene protein antibody
    • Follistatin-related protein 3 antibody
    • FSRP antibody
    • Fstl3 antibody
    • FSTL3_HUMAN antibody
    see all

References for Anti-FSTL3 antibody [RM0080-7D11] (ab86055)

ab86055 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry.

I heard back from the lab that the western was performed using mouse recombination protein, which gave a size at around 36 kDa in Western. Unfortunately we do not have the western image though.


I ho...

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