Overview

  • Product name
    Furosemide
  • Description
    Inhibitor of the Na+/2Cl-/K+ cotransporter. Also GABAA antagonist.
  • Biological description
    Inhibitor of the Na+/2Cl-/K+ cotransporter. Loop diuretic. Also acts as a non-competitive antagonist at GABAA receptors displaying approx. 100-fold greater selectivity for α6-containing receptors over α1-containing receptors.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Guyon A  et al. Furosemide modulation of GABA(A) receptors in dopaminergic neurones of the rat substantia nigra. Neuropharmacology 43:750-63 (2002). Read more (PubMed: 12367620) »
  • Thompson SA  et al. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Mol Pharmacol 55:993-9 (1999). Read more (PubMed: 10347239) »
  • Romano G  et al. The site of action of furosemide. Pharmacol Res 37:409-19 (1998). Read more (PubMed: 9642037) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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