Inhibitor of the Na+/2Cl-/K+ cotransporter. Also GABAA antagonist.
Inhibitor of the Na+/2Cl-/K+ cotransporter. Loop diuretic. Also acts as a non-competitive antagonist at GABAA receptors displaying approx. 100-fold greater selectivity for α6-containing receptors over α1-containing receptors.
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Guyon A et al. Furosemide modulation of GABA(A) receptors in dopaminergic neurones of the rat substantia nigra. Neuropharmacology43:750-63 (2002).
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Thompson SA et al. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Mol Pharmacol55:993-9 (1999).
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