• Product nameAnti-FZD3 antibody
    See all FZD3 primary antibodies
  • Description
    Mouse monoclonal to FZD3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 55-158 of Human FZD3



Our Abpromise guarantee covers the use of ab56331 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • Tissue specificityWidely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
    • Sequence similaritiesBelongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • DomainLys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • Cellular localizationMembrane. Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Frizzled 3 antibody
      • Frizzled 3 seven transmembrane spanning receptor antibody
      • Frizzled family receptor 3 antibody
      • Frizzled homolog 3 (Drosophila) antibody
      • Frizzled homolog 3 antibody
      • Frizzled-3 antibody
      • Frizzled3 antibody
      • Fz 3 antibody
      • Fz-3 antibody
      • Fz3 antibody
      • FZD 3 antibody
      • Fzd3 antibody
      • FZD3_HUMAN antibody
      • hFz 3 antibody
      • hFz3 antibody
      see all

    Anti-FZD3 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56331 FZD3 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-FZD3 antibody (ab56331)

    This product has been referenced in:
    • Valastyan S  et al. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137:1032-46 (2009). WB ; Human . Read more (PubMed: 19524507) »

    See 1 Publication for this product

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