Anti-G protein alpha inhibitor 1 antibody [2B8-2A5] (ab118434)

Overview

  • Product nameAnti-G protein alpha inhibitor 1 antibody [2B8-2A5]
    See all G protein alpha inhibitor 1 primary antibodies
  • Description
    Mouse monoclonal [2B8-2A5] to G protein alpha inhibitor 1
  • Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-354 of Human G protein alpha inhibitor 1 with proprietary tag (AAH26326).

  • Positive control
    • Human skin and adrenal tissues; Human liver tissue lysate; Recombinant Human G protein alpha inhibitor 1 protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab118434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 40 kDa.
IHC-P Use a concentration of 5 µg/ml.
ELISA Use at an assay dependent concentration.

Target

  • FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
  • Sequence similaritiesBelongs to the G-alpha family. G(i/o/t/z) subfamily.
  • Cellular localizationNucleus. Cytoplasm. Cell membrane. Cytoplasm > cytoskeleton > centrosome. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenylate cyclase inhibiting G alpha protein antibody
    • Adenylate cyclase inhibitory protein antibody
    • Adenylate cyclase-inhibiting G alpha protein antibody
    • G protein alpha inhibiting 1 antibody
    • G protein alpha inhibiting activity polypeptide 1 antibody
    • Gi antibody
    • Gi inhibitory G protein antibody
    • Gi1 protein alpha subunit antibody
    • GNAI 1 antibody
    • GNAI1 antibody
    • GNAI1_HUMAN antibody
    • Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 antibody
    • Guanine nucleotide binding protein alpha inhibiting activity polypeptide 1 antibody
    • Guanine nucleotide binding protein G(i) alpha 1 subunit antibody
    • Guanine nucleotide-binding protein G(i) subunit alpha-1 antibody
    • OTTHUMP00000161319 antibody
    • OTTHUMP00000208047 antibody
    see all

Anti-G protein alpha inhibitor 1 antibody [2B8-2A5] images

  • ab118434 at 5µg/ml staining G protein alpha inhibitor 1 in Formalin-fixed, Paraffin-embedded Human skin tissue by Immunohistochemistry.
  • ab118434 at 5µg/ml staining G protein alpha inhibitor 1 in Formalin-fixed, Paraffin-embedded Human adrenal tissue by Immunohistochemistry.
  • Anti-G protein alpha inhibitor 1 antibody [2B8-2A5] (ab118434) + Human liver tissue lysate

    Predicted band size : 40 kDa
  • Detection limit for recombinant tagged G protein alpha inhibitor 1 is approximately 1 ng/ml as a capture antibody.

References for Anti-G protein alpha inhibitor 1 antibody [2B8-2A5] (ab118434)

ab118434 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"