Application notesIs unsuitable for Flow Cyt,IHC or IP.
FunctionProbably involved in EGF and insulin receptor signaling.
Sequence similaritiesBelongs to the GAB family. Contains 1 PH domain.
Post-translational modificationsPhosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.
ab32093 at a 1:50 dilution staining GAB1 in PC-12 cells using immunofluoresence
References for Anti-GAB1 antibody [Y423] (ab32093)
This product has been referenced in:
Le Goff A et al. Anti-apoptotic Role of Caspase-cleaved GAB1 Adaptor Protein in Hepatocyte Growth Factor/Scatter Factor-MET Receptor Protein Signaling. J Biol Chem287:35382-96 (2012).
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