Overview

  • Product nameAnti-GABA A Receptor beta 3 antibody
    See all GABA A Receptor beta 3 primary antibodies
  • Description
    Rabbit polyclonal to GABA A Receptor beta 3
  • Tested applicationsSuitable for: ELISA, Flow Cyt, WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the N terminal domain of human GABA A Receptor beta 3.

  • General notes

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 23rd June 2017. The following lots are still unpurified and still in stock as of 23rd June 2017 - GR325257-1, GR325257-2, GR325257-3, GR325257-4, GR325257-5, GR325257-6, GR1530-9, GR1530-10. Lot numbers other than GR325257-1, GR325257-2, GR325257-3, GR325257-4, GR325257-5, GR325257-6, GR1530-9, GR1530-10 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.

Properties

Applications

Our Abpromise guarantee covers the use of ab66430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration. PubMed: 22563490
Flow Cyt Use at an assay dependent concentration. PubMed: 22563490ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
WB 1/500 - 1/5000. Predicted molecular weight: 54 kDa.
IHC-P 1/100 - 1/500.
IHC-Fr 1/100 - 1/500.

Target

  • FunctionComponent of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
  • Involvement in diseaseEpilepsy, childhood absence 5
  • Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily.
  • Cellular localizationCell junction, synapse, postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ECA5 antibody
    • GABA alpha receptor beta-2 subunit antibody
    • GABA(A) receptor subunit beta-3 antibody
    • GABAA receptor beta 3 subunit antibody
    • GABAA receptor subunit beta 3 antibody
    • GABR B3 antibody
    • Gabrb3 antibody
    • Gamma aminobutyric acid (GABA) A receptor beta 3 antibody
    • Gamma aminobutyric acid receptor subunit beta 3 antibody
    • Gamma-aminobutyric acid receptor subunit beta-3 antibody
    • GBRB3_HUMAN antibody
    • MGC9051 antibody
    see all

References for Anti-GABA A Receptor beta 3 antibody (ab66430)

This product has been referenced in:
  • Desrues L  et al. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PLoS One 7:e36319 (2012). ELISA, Flow Cyt ; Human . Read more (PubMed: 22563490) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"