Anti-GABA A Receptor delta antibody (ab110014)

Overview

  • Product nameAnti-GABA A Receptor delta antibody
    See all GABA A Receptor delta primary antibodies
  • Description
    Rabbit polyclonal to GABA A Receptor delta
  • SpecificityDetects endogenous levels of total GABA A Receptor delta protein
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    A synthesized peptide derived from an internal sequence of human GABA A Receptor delta

  • Positive control
    • Extracts from LOVO or HT29 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab110014 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 50 kDa.

Target

  • FunctionGABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • Involvement in diseaseDefects in GABRD are the cause of susceptibility to generalized epilepsy with febrile seizures plus type 5 (GEFS+5) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
    Defects in GABRD are the cause of susceptibility to idiopathic generalized epilepsy type 10 (IGE10) [MIM:613060]. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
    Defects in GABRD are the cause of susceptibility to juvenile myoclonic epilepsy type 7 (EJM7) [MIM:613060]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
  • Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily.
  • Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GABA(A) receptor subunit delta antibody
    • Gabrd antibody
    • Gamma aminobutyric acid GABA A receptor delta antibody
    • Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor antibody
    • Gamma-aminobutyric acid receptor subunit delta antibody
    • GBRD_HUMAN antibody
    • MGC45284 antibody
    see all

Anti-GABA A Receptor delta antibody images

  • All lanes : Anti-GABA A Receptor delta antibody (ab110014) at 1/500 dilution

    Lane 1 : extracts from HT29 cells (5-30 ug total protein) with no immunizing peptide
    Lane 2 : extracts from LOVO cells (5-30 ug total protein) with no immunizing peptide
    Lane 3 : extracts from LOVO cells (5-30 ug total protein) with immunizing peptide (5-10 ug)


    Predicted band size : 50 kDa

References for Anti-GABA A Receptor delta antibody (ab110014)

ab110014 has not yet been referenced specifically in any publications.

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