GABA and Glutamate Antagonists Kit (ab120376)

Overview

  • Product nameGABA and Glutamate Antagonists Kit
    See all Metabotropic glutamate receptor kits
  • SpecificityA collection of 5 antagonists for Glutamate and GABA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM, respectively. The kit contains LY 341495 sodium salt (ab120400), D-AP5 (ab120003), NBQX disodium salt (ab120046), (-)-Bicuculline methochloride (ab120110) and CGP 52432 (ab120330).
  • Product overview

    A collection of 5 antagonists for Glutamate and GABA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM respectively. The kit contains LY 341495 sodium salt (ab120400), D-AP5 (ab120003), NBQX disodium salt (ab120046), (-)-Bicuculline methochloride (ab120110) and CGP 52432 (ab120330).   

    Receptor description 

    All mGlu (mGlu1,2,3,4,5,6,7,8) 

    LY 341495 sodium salt: Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values are 1.67, 0.75, 31.6, 72.7, 14 nM at human mGlu2, mGlu3, mGlu6, mGlu7a, and human mGlu8a receptors respectively. IC50 values are 7.8, 8.2 and 22 µM for mGlu1a, mGlu5a and mGlu4 receptors. Readily brain penetrant and active in vivo. Suggested Solvent: Water  

    NMDA 

    D-AP5: Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5. Suggested Solvent: Water  

    AMPA/Kainate 

    NBQX disodium salt: Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo. Suggested Solvent: Water 

    GABAA 

     (-)-Bicuculline methochloride: Water-soluble GABAA antagonist. Methochloride salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported. Suggested Solvent: Water  

    GABAB 

    CGP 52432: Potent, selective GABAB antagonist (IC50 = 85 nM). Suggested Solvent: Water

Properties

  • RelevanceMetabotropic Glutamate Receptor contains a Periplasmic Binding Protein Type 1 region, which belongs to Type 1 periplasmic binding fold superfamily. This model and hierarchy represent the ligand binding domains of the LacI family of transcriptional regulators, periplasmic binding proteins of the ABC-type transport systems.
  • Alternative names
    • GluR
    • Smp_128940

References for GABA and Glutamate Antagonists Kit (ab120376)

ab120376 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

These products are freeze dried to an exact weight so adding 0.5 ml in each product will give you conc. of 10 mM.

0.5 ml addition of water or solvent into each product will give 10 mM solution.
Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"