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A collection of 5 antagonists for Glutamate and GABA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM respectively. The kit contains LY 341495 sodium salt (ab120400), D-AP5 (ab120003), NBQX disodium salt (ab120046), (-)-Bicuculline methochloride (ab120110) and CGP 52432 (ab120330).
All mGlu (mGlu1,2,3,4,5,6,7,8)
LY 341495 sodium salt: Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values are 1.67, 0.75, 31.6, 72.7, 14 nM at human mGlu2, mGlu3, mGlu6, mGlu7a, and human mGlu8a receptors respectively. IC50 values are 7.8, 8.2 and 22 µM for mGlu1a, mGlu5a and mGlu4 receptors. Readily brain penetrant and active in vivo. Suggested Solvent: Water
D-AP5: Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5. Suggested Solvent: Water
NBQX disodium salt: Water soluble, potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo. Suggested Solvent: Water
(-)-Bicuculline methochloride: Water-soluble GABAA antagonist. Methochloride salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported. Suggested Solvent: Water
CGP 52432: Potent, selective GABAB antagonist (IC50 = 85 nM). Suggested Solvent: Water
|ab120110 - (-)-Bicuculline methochloride||1 vial|
|ab120330 - CGP 52432||1 vial|
|ab120003 - D-AP5||1 vial|
|ab120400 - LY 341495 sodium salt||1 vial|
|ab120046 - NBQX disodium salt||1 vial|
ab120376 has not yet been referenced specifically in any publications.