Overview

  • Product name
  • Description
    Chicken polyclonal to GABA
  • Specificity
    Fixed tissue cross-reactivity tested with known targets at recommended dilution. No measurable glutaraldehyde-fixed tissue cross-reactivity (<1:1000) against: L-alanine, D/L-aspartate, agmatine, D/L-arginine, L-citrulline, L-cysteine, D/L-glutamate, D/L-glutamine, glutathione, glycine, L-histidine, L-isoleucine, L-lysine, L-leucine, L-methionine, L-asparagine, L-ornithine, L-proline, L-serine, taurine, L-threonine, L-valine, L-tryptophan, L-tyrosine. No measurable reactivity against formaldehyde fixed proteins
  • Tested applications
    Suitable for: ICCmore details
  • Species reactivity
    Not applicable.
  • Immunogen

    4-aminobutyrate cross-linked to purifed fraction V bovine serum albumin with glutaraldehyde.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.05% Thimerosal (merthiolate)
    Constituents: 100mM PBS
  • Concentration information loading...
  • Purity
    IgY fraction
  • Purification notes
    IgYs were separated from other yolk proteins by serial PEG6000 extractions using a modification of the method of Polsonet al Immunological Investigations.
  • Clonality
    Polyclonal
  • Isotype
    IgY
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab62669 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC
  • Application notes
    Endogenous content mapping by LM and EM ICC: 1/100. True dilution at user dilution: 1/32000. Optimal fixation: 0.1-2.5% glutaraldehyde,1% formaldehyde using HPI (High Performance Immunocytochemistry).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABA acts at inhibitory synapses in the brain and spinal cord. Inhibition is provoked by GABA binding resulting in hyperpolarization of the synaptic transmembrane potential of the affected neuron. GABA binding causes ion channels to open allowing either the flow of chloride or potassium ions into or out of the cell.
    • Cellular localization
      Cell Membrane, Cytoplasmic, Plasma membrane and Secreted
    • Alternative names
      • 4 aminobutanoic acid antibody
      • GABA antibody
      • Gamma amino butyric acid antibody
      • Gamma aminobutyric acid antibody

    References

    ab62669 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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