Anti-GABA B Receptor 2 (phospho S884) antibody [EP2317Y] (ab68425)


  • Product nameAnti-GABA B Receptor 2 (phospho S884) antibody [EP2317Y]
    See all GABA B Receptor 2 primary antibodies
  • Description
    Rabbit monoclonal [EP2317Y] to GABA B Receptor 2 (phospho S884)
  • SpecificityDetectes GABA B Receptor 2 only when phosphorylated at serine 884
  • Tested applicationsSuitable for: WB, IP, ICC/IFmore details
    Unsuitable for: Flow Cyt or IHC-P
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic phosphopeptide corresponding to residues surrounding serine 884 of Human GABA B Receptor 2.

  • Positive control
    • Brain
  • General notes

    This product is a recombinant rabbit monoclonal antibody.


    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab68425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2500 - 1/5000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
IP 1/30.
ICC/IF 1/100 - 1/250.
  • Application notesIs unsuitable for Flow Cyt or IHC-P.
  • Target

    • FunctionReceptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
    • Tissue specificityHighly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
    • Sequence similaritiesBelongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
    • DomainAlpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
    • Cellular localizationCell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • BcDNA:GH07312 antibody
      • CG6706 antibody
      • CT20836 antibody
      • D Gaba2 antibody
      • FLJ36928 antibody
      • G protein coupled receptor 51 antibody
      • G-protein coupled receptor 51 antibody
      • GAB B R2 antibody
      • GABA B R2 antibody
      • GABA B receptor 2 antibody
      • GABA-B receptor 2 antibody
      • GABA-B-R2 antibody
      • GABA-BR2 antibody
      • GABAB R2 antibody
      • GABABR 2 antibody
      • GABABR2 antibody
      • GABB R2 antibody
      • GABBR 2 antibody
      • Gabbr2 antibody
      • GABR2_HUMAN antibody
      • Gamma aminobutyric acid B receptor 2 antibody
      • Gamma aminobutyric acid GABA B receptor 2 antibody
      • Gamma aminobutyric acid type B receptor subunit 2 antibody
      • Gamma-aminobutyric acid type B receptor subunit 2 antibody
      • Gb 2 antibody
      • Gb2 antibody
      • GH07312 antibody
      • GPR 51 antibody
      • GPR51 antibody
      • GPRC 3B antibody
      • GPRC3B antibody
      • HG 20 antibody
      • HG20 antibody
      • HRIHFB2099 antibody
      • Metabotropic GABA B receptor subtype 2 antibody
      • OTTHUMP00000021776 antibody
      • OTTHUMP00000063797 antibody
      • R2 SUBUNIT antibody
      see all

    Anti-GABA B Receptor 2 (phospho S884) antibody [EP2317Y] images

    • All lanes : Anti-GABA B Receptor 2 (phospho S884) antibody [EP2317Y] (ab68425) at 1/5000 dilution

      Lane 1 : Untreated Human brain lysate
      Lane 2 : AP-treated Human brain lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled Goat anti-Rabbit at 1/2000 dilution

      Predicted band size : 106 kDa
      Observed band size : 106 kDa

    References for Anti-GABA B Receptor 2 (phospho S884) antibody [EP2317Y] (ab68425)

    ab68425 has not yet been referenced specifically in any publications.

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