Cell-permeable potassium channel modulator. Neuroprotective agent reported to reduce oxygen glucose deprivation-induced [3H]glutamate release in rat ischemia hippocampal slices. Improves motor performance in a transgenic mouse model of Huntington’s disease. Neuroprotective characteristics take effect via opening of ATP-sensitive potassium channels.
Store at Room Temperature. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Pielen A et al. Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels. Graefes Arch Clin Exp Ophthalmol242:240-4 (2004).
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Zucker B et al. Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington's disease. Naunyn Schmiedebergs Arch Pharmacol370:131-9 (2004).
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Jehle T et al. Gabapentin-lactam (8-aza-spiro[5,4]decan-9-on; GBP-L) inhibits oxygen glucose deprivation-induced [3H]glutmate release and is a neuroprotective agent in amodel of acute retinal ischemia. Naunyn Schmiedebergs Arch Pharmacol362:74-81 (2000).
Read more (PubMed: 10935536) »