Overview

  • Product name
    Gabapentin lactam
  • Description
    Cell-permeable potassium channel modulator. Neuroprotective agent.
  • Biological description

    Cell-permeable potassium channel modulator. Neuroprotective agent reported to reduce oxygen glucose deprivation-induced [3H]glutamate release in rat ischemia hippocampal slices. Improves motor performance in a transgenic mouse model of Huntington’s disease. Neuroprotective characteristics take effect via opening of ATP-sensitive potassium channels.

Properties

  • Molecular weight
    153.22
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C9H15NO
  • CAS Number
    64744-50-9
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=C2CC1(CCCCC1)CN2
  • Source

    Synthetic

References

This product has been referenced in:
  • Pielen A  et al. Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels. Graefes Arch Clin Exp Ophthalmol 242:240-4 (2004). Read more (PubMed: 14770318) »
  • Zucker B  et al. Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington's disease. Naunyn Schmiedebergs Arch Pharmacol 370:131-9 (2004). Read more (PubMed: 15322735) »
  • Lagrèze WA  et al. The neuroprotective properties of gabapentin-lactam. Graefes Arch Clin Exp Ophthalmol 239:845-9 (2001). Read more (PubMed: 11789865) »
  • Jehle T  et al. Gabapentin-lactam (8-aza-spiro[5,4]decan-9-on; GBP-L) inhibits oxygen glucose deprivation-induced [3H]glutmate release and is a neuroprotective agent in amodel of acute retinal ischemia. Naunyn Schmiedebergs Arch Pharmacol 362:74-81 (2000). Read more (PubMed: 10935536) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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