GABAA receptor agonist and GABAC receptor antagonist
Biological descriptionGABAA receptor agonist and GABAC receptor antagonist. Antinociceptive, anticonvulsant and hypnotic agent. Blood-brain barrier permeable. Active in vivo and in vitro.
Chemical name4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Gaboxadol hydrochloride (THIP hydrochloride) (ab120426)
This product has been referenced in:
Morishita W & Sastry BR Postsynaptic mechanisms underlying long-term depression of GABAergic transmission in neurons of the deep cerebellar nuclei. J Neurophysiol76:59-68 (1996).
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