Anti-GAD65 antibody - Neuronal Marker (ab2348)

Overview

  • Product nameAnti-GAD65 antibody - Neuronal Marker
    See all GAD65 primary antibodies
  • Description
    Rabbit polyclonal to GAD65 - Neuronal Marker
  • SpecificityThis antibody reacts with a 65 kD protein, known as GAD (Glutamate Decarboxylase)
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide (Human).

  • Positive control
    • Pancreas
  • General notes


    Two forms of GAD exist in adults, GAD 65 and GAD 67, which are encoded by different genes. GAD 65 and GAD 67 are expressed in most GABA containing neurons. GAD 65 appears to be targeted to the membrane and nerve ending, where as GAD 67 is more widely distributed throughout the cell.

Properties

Applications

Our Abpromise guarantee covers the use of ab2348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • FunctionCatalyzes the production of GABA.
  • Sequence similaritiesBelongs to the group II decarboxylase family.
  • Post-translational
    modifications
    Phosphorylated; which does not affect kinetic parameters or subcellular location.
    Palmitoylated; which is required for presynaptic clustering.
  • Cellular localizationCytoplasm > cytosol. Cytoplasmic vesicle. Cell junction > synapse > presynaptic cell membrane. Golgi apparatus membrane. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
  • Information by UniProt
  • Database links
  • Alternative names
    • 65 kDa glutamic acid decarboxylase antibody
    • DCE 2 antibody
    • DCE2 antibody
    • DCE2_HUMAN antibody
    • GAD 2 antibody
    • GAD 65 antibody
    • GAD-2 antibody
    • GAD-65 antibody
    • Gad2 antibody
    • Glutamate decarboxylase 2 (pancreas) antibody
    • Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa) antibody
    • Glutamate decarboxylase 2 antibody
    • Glutamate Decarboxylase 65 antibody
    • Glutamate decarboxylase 65 kDa isoform antibody
    • Glutamic Acid Decarboxylase 2 antibody
    • Glutamic Acid Decarboxylase 65 antibody
    • MGC161605 antibody
    • MGC161607 antibody
    see all

Anti-GAD65 antibody - Neuronal Marker images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas tissue, staining GAD65 with ab2348.

References for Anti-GAD65 antibody - Neuronal Marker (ab2348)

ab2348 has not yet been referenced specifically in any publications.

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