FunctionBinds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.
Tissue specificityPeripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin disease tissue.
Sequence similaritiesContains 2 galectin domains.
DomainContains two homologous but distinct carbohydrate-binding domains.
Cellular localizationCytoplasm. Secreted. May also be secreted by a non-classical secretory pathway.