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Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.
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Tissue specificity
Widely expressed. Expressed at high level in small intestine, and at intermediate levels in stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues.
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Pathway
Protein modification; protein glycosylation.
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Sequence similarities
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Contains 1 ricin B-type lectin domain.
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Domain
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
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Cellular localization
Golgi apparatus membrane.
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Information by UniProt
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Database links
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Alternative names
- DKFZp586H0623 antibody
- FLJ00205 antibody
- FLJ11715 antibody
- GalNAc T10 antibody
- GalNAc transferase 10 antibody
- GalNAc-T10 antibody
- GalNAcT10 antibody
- GALNT10 antibody
- GLT10_HUMAN antibody
- Polypeptide GalNAc transferase 10 antibody
- Polypeptide N-acetylgalactosaminyltransferase 10 antibody
- pp GalNAc T10 antibody
- pp GaNTase 10 antibody
- pp-GaNTase 10 antibody
- ppGalNAcT10 antibody
- ppGaNTase 10 antibody
- Protein UDP acetylgalactosaminyltransferase 10 antibody
- Protein-UDP acetylgalactosaminyltransferase 10 antibody
- UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 10 antibody
- UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 10 antibody
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10 antibody
- UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) antibody
see all