Anti-GALNT11 antibody - N-terminal (ab173710)

Overview

  • Product name
    Anti-GALNT11 antibody - N-terminal
    See all GALNT11 primary antibodies
  • Description
    Rabbit polyclonal to GALNT11 - N-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human GALNT11 aa 109-138 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q8NCW6

  • Positive control
    • HeLa cell lysate; Mouse kidney tissue lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab173710 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab173710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 69 kDa.

Target

  • Function
    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward Muc1, Muc4.1, and EA2 than GALNT1. Does not appear to be involved in glycosylation of erythropoietin.
  • Tissue specificity
    Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli.
  • Pathway
    Protein modification; protein glycosylation.
  • Sequence similarities
    Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • Domain
    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • A430075I06Rik antibody
    • AI648252 antibody
    • E430002F06Rik antibody
    • FLJ21634 antibody
    • GalNAc Transferase 11 antibody
    • GalNAc-T11 antibody
    • GalNAcT11 antibody
    • GALNT11 antibody
    • GLT11_HUMAN antibody
    • MGC71630 antibody
    • Polypeptide GalNAc transferase 11 antibody
    • Polypeptide N-acetylgalactosaminyltransferase 11 antibody
    • pp-GaNTase 11 antibody
    • Protein-UDP acetylgalactosaminyltransferase 11 antibody
    • tcag7.1057 antibody
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11 antibody
    • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) antibody
    see all

Images

  • Anti-GALNT11 antibody - N-terminal (ab173710) at 1/100 dilution + Mouse kidney tissue lysate at 35 µg

    Predicted band size : 69 kDa
  • Anti-GALNT11 antibody - N-terminal (ab173710) at 1/100 dilution + HeLa cell lysate at 35 µg

    Predicted band size : 69 kDa

References

ab173710 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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