Overview

  • Product name
  • Description
    Rabbit polyclonal to GALNT2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Zebrafish
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 55-339 of Human GALNT2 (NP_004472)

  • Positive control
    • HepG2, Molt-4 and Raji cells

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG

Applications

Our Abpromise guarantee covers the use of ab97741 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 65 kDa.

Target

  • Function
    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.
  • Tissue specificity
    Widely expressed.
  • Pathway
    Protein modification; protein glycosylation.
  • Sequence similarities
    Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • Domain
    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Cellular localization
    Golgi apparatus > Golgi stack membrane. Secreted. Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
  • Information by UniProt
  • Database links
  • Alternative names
    • GalNAc T2 antibody
    • GalNAc-T2 antibody
    • Galnt2 antibody
    • GALT2_HUMAN antibody
    • GaNTase 2 antibody
    • Polypeptide GalNAc transferase 2 antibody
    • Polypeptide N acetylgalactosaminyltransferase 2 antibody
    • Polypeptide N acetylgalactosaminyltransferase 2 soluble form antibody
    • Polypeptide N-acetylgalactosaminyltransferase 2 soluble form antibody
    • pp GaNTase 2 antibody
    • pp-GaNTase 2 antibody
    • Protein UDP acetylgalactosaminyltransferase 2 antibody
    • Protein-UDP acetylgalactosaminyltransferase 2 antibody
    • UDP GalNAc transferase 2 antibody
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 2 (GalNAc T2) antibody
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 2 antibody
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 antibody
    see all

Images

  • Anti-GALNT2 antibody (ab97741) at 1/500 dilution + Molt-4 whole cell lysate at 30 µg

    Predicted band size : 65 kDa

References

ab97741 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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