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gamma Catenin peptide - phospho Y550 (ab42715)

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Overview

  • Product namegamma Catenin peptide - phospho Y550See all gamma Catenin proteins and peptides ...
  • Protein descriptionSynthetic peptide corresponding to amino acids around Tyrosine 550 of human gamma Catenin. (This peptide sequence is highly conserved in rat and mouse gamma Catenin). This peptide was used as an immunogen for ab29041 - gamma Catenin (phospho Y550) antibody.

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Biological activityThis peptide sequence is highly conserved in rat and mouse gamma Catenin.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.05% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab42715 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    ICC/IF
    Blocking
    ELISA
  • Application notesBL: Use at a concentration of 1 µg/ml. (Western blot and immunocytochemistry).
    ELISA: Use at a concentration of 10-100 ng/well.
    ICC/IF: Use at a concentration of 1 µg/ml.
    WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 81 kDa.
    This peptide blocks the activity of ab29041.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        ARVD 12ARVD12Catenin (cadherin associated protein), gamma 80kDa
        catenin (cadherin-associated protein) gamma (80kD)Catenin gammaCTNNGDesmoplakin 3Desmoplakin IIIDesmoplakin-3Desmoplakin3DesmoplakinIIIDP 3DP IIIDP3DPIIIgamma cateninJunction plakoglobinJUPOTTHUMP00000164732OTTHUMP00000164735OTTHUMP00000164738PDGBPKGBPLAK_HUMANPLAKOGLOBIN
      see all
  • FunctionCommon junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
  • Involvement in diseaseDefects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.
    Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • Sequence similaritiesBelongs to the beta-catenin family.
    Contains 9 ARM repeats.
  • Cellular localizationCell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane. Cytoplasmic in a soluble and membrane-associated form.

    • Target information above from: UniProt accession P14923 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for gamma Catenin peptide - phospho Y550 (ab42715)

    ab42715 has not yet been referenced specifically in any publications.

    Publishing research using ab42715 ? Please let us know so that we can cite the reference in this datasheet

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