Anti-gamma H2A.X (phospho S139) antibody (ab11174)

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ab11174 has been referenced in 71 publications.

  • Maierhofer A  et al. Analysis of global DNA methylation changes in primary human fibroblasts in the early phase following X-ray irradiation. PLoS One 12:e0177442 (2017). ICC/IF ; Human . PubMed: 28489894
  • Kotzur T  et al. Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy. Reprod Biol Endocrinol 15:7 (2017). ICC/IF ; Mouse . PubMed: 28077131
  • Pal D  et al. TGF-ß reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells. Elife 6:N/A (2017). ICC/IF ; Human . PubMed: 28092266
  • Rakhimova A  et al. Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks. Sci Rep 7:43750 (2017). WB ; Dictyostelium discoideum . PubMed: 28252050
  • Xiong H  et al. Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization. J Cancer 8:345-353 (2017). WB ; Human . PubMed: 28261334
  • Jangi M  et al. SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage. Proc Natl Acad Sci U S A 114:E2347-E2356 (2017). WB ; Human . PubMed: 28270613
  • Doi H  et al. Pravastatin reduces radiation-induced damage in normal tissues. Exp Ther Med 13:1765-1772 (2017). PubMed: 28565765
  • Gao X  et al. UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo. Oncotarget 7:32543-53 (2016). PubMed: 27105523
  • Flynn RA  et al. 7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol 23:231-8 (2016). PubMed: 26878240
  • Francia S  et al. DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors. J Cell Sci 129:1468-76 (2016). PubMed: 26906421
  • Shah S  et al. Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS. J Biol Chem 291:110-25 (2016). WB ; Mouse . PubMed: 26546680
  • Zhang H  et al. Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. PLoS One 11:e0167454 (2016). WB, ICC/IF ; Human . PubMed: 27907109
  • Skrdlant L  et al. Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C. BMC Mol Biol 17:18 (2016). ICC/IF ; Human . PubMed: 27552991
  • Soo Lee N  et al. TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage. Nat Commun 7:10463 (2016). IHC . PubMed: 26781088
  • Piya S  et al. Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Blood 128:1260-9 (2016). PubMed: 27268264
  • Gunn AR  et al. The role of ADP-ribosylation in regulating DNA interstrand crosslink repair. J Cell Sci 129:3845-3858 (2016). PubMed: 27587838
  • Detappe A  et al. Key clinical beam parameters for nanoparticle-mediated radiation dose amplification. Sci Rep 6:34040 (2016). IHC-P ; Mouse . PubMed: 27658637
  • Wilson R  et al. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun 7:13597 (2016). ICC/IF ; Human . PubMed: 27886180
  • Gao R  et al. Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. PLoS Genet 11:e1004834 (2015). WB ; Human . PubMed: 25590633
  • Doldi V  et al. Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation. Oncotarget 6:31441-60 (2015). ICC/IF ; Human . PubMed: 26375444
  • Chayka O  et al. Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells. J Biol Chem 290:2198-212 (2015). WB ; Human . PubMed: 25477524
  • Cui J  et al. Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models. Sci Rep 5:11256 (2015). WB . PubMed: 26052900
  • Kropp J  et al. Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice. PLoS One 10:e0142588 (2015). WB ; Mouse . PubMed: 26544188
  • Levring TB  et al. Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis. Oncotarget 6:21853-64 (2015). WB . PubMed: 26392411
  • Sutherland JM  et al. RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus. FASEB J 29:2759-68 (2015). PubMed: 25782991
  • Moiseeva O  et al. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle 14:2408-21 (2015). PubMed: 26029982
  • Collins JK  et al. DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint. Nat Commun 6:8553 (2015). IF . PubMed: 26522232
  • Shirazi Fard S  et al. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle 13:408-17 (2014). IHC . PubMed: 24247150
  • Rengaraj D  et al. Small non-coding RNA profiling and the role of piRNA pathway genes in the protection of chicken primordial germ cells. BMC Genomics 15:757 (2014). ICC . PubMed: 25185950
  • Bao J  et al. RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility. PLoS Genet 10:e1004825 (2014). PubMed: 25474150
  • Loughery J  et al. Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters. Nucleic Acids Res 42:7666-80 (2014). WB . PubMed: 24928858
  • Hilliard SA  et al. Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol 387:1-14 (2014). PubMed: 24440154
  • Shirazi Fard S  et al. The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest. Cell Cycle 13:3698-706 (2014). IHC . PubMed: 25483080
  • Vasudevarao MD  et al. Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis. J Biol Chem 289:7702-17 (2014). WB . PubMed: 24469461
  • Sutherland JM  et al. Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression. Biol Reprod 90:92 (2014). IHC-P ; Mouse . PubMed: 24671879
  • Lu H  et al. Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. Cell Death Dis 5:e1226 (2014). WB, ICC/IF ; Human . PubMed: 24832598
  • Kalamida D  et al. Important role of autophagy in endothelial cell response to ionizing radiation. PLoS One 9:e102408 (2014). ICC/IF ; Human . PubMed: 25010689
  • Datta S  et al. Distinct distribution pattern of hepatitis B virus genotype C and D in liver tissue and serum of dual genotype infected liver cirrhosis and hepatocellular carcinoma patients. PLoS One 9:e102573 (2014). ICC/IF ; Human . PubMed: 25032957
  • Gangoda L  et al. Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice. Cell Death Differ N/A:N/A (2014). PubMed: 25012505
  • Vassileva I  et al. The mammalian INO80 chromatin remodeling complex is required for replication stress recovery. Nucleic Acids Res 42:9074-86 (2014). ICC/IF ; Human . PubMed: 25016522
  • Katsogiannou M  et al. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Mol Cell Proteomics 13:3585-601 (2014). WB . PubMed: 25277244
  • Ivanov A  et al. Lysosome-mediated processing of chromatin in senescence. J Cell Biol 202:129-43 (2013). PubMed: 23816621
  • Zhang X  et al. Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. J Biol Chem 288:22042-56 (2013). PubMed: 23737518
  • Boohaker RJ  et al. ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity. Radiother Oncol N/A:N/A (2013). PubMed: 23891091
  • Couto CA  et al. Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks. J Cell Sci 126:3452-61 (2013). PubMed: 23750002
  • Zhu J  et al. Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow. PLoS One 8:e71153 (2013). ICC/IF ; Mouse . PubMed: 23940708
  • Rosner A  et al. Germ lineage properties in the urochordate Botryllus schlosseri - From markers to temporal niches. Dev Biol 384:356-74 (2013). PubMed: 24120376
  • Mitchell JK  et al. Baculovirus F-box protein LEF-7 modifies the host DNA damage response to enhance virus multiplication. J Virol 87:12592-9 (2013). PubMed: 24027328
  • Heylmann D  et al. Human CD4+CD25+ regulatory T cells are sensitive to low dose cyclophosphamide: implications for the immune response. PLoS One 8:e83384 (2013). ICC/IF . PubMed: 24376696
  • Rantala JK  et al. Expanding the Diversity of Imaging-Based RNAi Screen Applications Using Cell Spot Microarrays. Microarrays (Basel) 2:97-114 (2013). PubMed: 27605183
  • Liu H  et al. A method for systematic mapping of protein lysine methylation identifies functions for HP1ß in DNA damage response. Mol Cell 50:723-35 (2013). PubMed: 23707759
  • Müller LU  et al. Overcoming reprogramming resistance of Fanconi anemia cells. Blood 119:5449-57 (2012). PubMed: 22371882
  • Mitchell JK & Friesen PD Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication. J Virol 86:13542-53 (2012). PubMed: 23035220
  • Sheu JJ  et al. Mutant BRAF induces DNA strand breaks, activates DNA damage response pathway, and up-regulates glucose transporter-1 in nontransformed epithelial cells. Am J Pathol 180:1179-88 (2012). PubMed: 22227015
  • Gavvovidis I  et al. A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells. PLoS One 7:e40387 (2012). Human . PubMed: 22952573
  • Ring H  et al. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7:e36874 (2012). ICC/IF ; Chicken . PubMed: 22590629
  • Zhang YW  et al. Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res 39:3607-20 (2011). Flow Cyt . PubMed: 21227924
  • Hu Y  et al. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev 25:685-700 (2011). WB, ICC/IF . PubMed: 21406551
  • Colpitts TM  et al. Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells. PLoS One 6:e24365 (2011). WB ; Human . PubMed: 21909430
  • Kirwan M  et al. Dyskeratosis congenita and the DNA damage response. Br J Haematol 153:634-43 (2011). Flow Cyt ; Human . PubMed: 21477209
  • Quennet V  et al. CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. Nucleic Acids Res 39:2144-52 (2011). ICC/IF ; Human . PubMed: 21087997
  • Auer S  et al. Survival of tumor cells after proton irradiation with ultra-high dose rates. Radiat Oncol 6:139 (2011). IF . PubMed: 22008289
  • Kossatz U  et al. The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells. J Clin Invest 120:3820-33 (2010). PubMed: 20978349
  • Sheu JJ  et al. Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability. J Biol Chem 285:38260-9 (2010). ICC/IF ; Human . PubMed: 20923775
  • Folini M  et al. Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer. Biochem Pharmacol 79:1781-90 (2010). ICC/IF ; Human . PubMed: 20206144
  • Folini M  et al. miR-21: an oncomir on strike in prostate cancer. Mol Cancer 9:12 (2010). ICC/IF ; Human . PubMed: 20092645
  • Yoshimura K  et al. Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). Proc Natl Acad Sci U S A 106:9280-5 (2009). ICC/IF ; Mouse . PubMed: 19470456
  • Sacchetti P  et al. Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell 5:409-19 (2009). WB ; Mouse . PubMed: 19796621
  • Lee Y & McKinnon PJ Detection of apoptosis in the central nervous system. Methods Mol Biol 559:273-82 (2009). PubMed: 19609763
  • Alton M  et al. The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.Y(TIR)sex-reversed mouse ovary. Reproduction 135:241-52 (2008). PubMed: 18239052
  • McManus KJ & Hendzel MJ ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells. Mol Biol Cell 16:5013-25 (2005). ICC/IF . PubMed: 16030261

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