Overview

  • Product nameAnti-gamma Synuclein antibody
    See all gamma Synuclein primary antibodies
  • Description
    Sheep polyclonal to gamma Synuclein
  • SpecificityThe peptide sequence was chosen to achieve a high level of specificity in the antiserum. Specificity also has been demonstrated by immunohistochemistry and western blot.
  • Tested applicationsSuitable for: WB, ELISA, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide:

    EKEEVAEEAQSGGD

    , corresponding to C terminal amino acids 114-127 of Human gamma Synuclein. This peptide was conjugated to carrier protein to enhance the immunological response.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab49206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 3 µg/ml. Predicted molecular weight: 13 kDa.
ELISA Use a concentration of 1 µg/ml.
IHC-Fr Use a concentration of 3 - 5 µg/ml.

Target

  • FunctionPlays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.
  • Tissue specificityHighly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
  • Sequence similaritiesBelongs to the synuclein family.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
  • Cellular localizationCytoplasm > perinuclear region. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
  • Information by UniProt
  • Database links
  • Alternative names
    • BCSG1 antibody
    • Breast cancer specific gene 1 protein antibody
    • Breast cancer specific protein 1 antibody
    • Breast cancer-specific gene 1 protein antibody
    • Gamma synuclein antibody
    • Gamma-synuclein antibody
    • Persyn antibody
    • PRSN antibody
    • SNCG antibody
    • SR antibody
    • Synoretin antibody
    • Synuclein gamma antibody
    • synuclein, gamma (breast cancer-specific protein 1) antibody
    • SYUG_HUMAN antibody
    see all

References for Anti-gamma Synuclein antibody (ab49206)

This product has been referenced in:
  • Wilding C  et al. ?-Synuclein antibodies have neuroprotective potential on neuroretinal cells via proteins of the mitochondrial apoptosis pathway. PLoS One 9:e90737 (2014). Read more (PubMed: 24595072) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"