Recombinant
RabMAb

Anti-GAMT antibody [EPR6925] (ab126736)

Overview

  • Product name
    Anti-GAMT antibody [EPR6925]
    See all GAMT primary antibodies
  • Description
    Rabbit monoclonal [EPR6925] to GAMT
  • Tested applications
    Suitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt,ICC/IF or IP
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to amino acid residues in Human GAMT.

  • Positive control
    • Human fetal liver, HepG2 and SH-SY5Y lysates; Human liver tissue.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab126736 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 26 kDa (predicted molecular weight: 26 kDa).
IHC-P 1/100 - 1/250.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IP.
  • Target

    • Tissue specificity
      Expressed in liver.
    • Pathway
      Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2.
    • Involvement in disease
      Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency (GAMT deficiency) [MIM:612736]. GAMT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid (GAA) in brain and body fluids.
    • Sequence similarities
      Belongs to the RMT2 methyltransferase family.
    • Information by UniProt
    • Database links
    • Alternative names
      • CCDS2 antibody
      • Epididymis secretory protein Li 20 antibody
      • GAMT antibody
      • GAMT_HUMAN antibody
      • Guanidinoacetate N methyltransferase antibody
      • Guanidinoacetate N-methyltransferase antibody
      • HEL-S-20 antibody
      • PIG2 antibody
      • TP53I2 antibody
      see all

    Images

    • All lanes : Anti-GAMT antibody [EPR6925] (ab126736) at 1/1000 dilution

      Lane 1 : Human fetal liver Lysate
      Lane 2 : HepG2 lysate
      Lane 3 : SH-SY5Y lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat-anti-rabbit HRP at 1/2000 dilution
      Developed using the ECL technique

      Predicted band size : 26 kDa
    • ab126736 at 1/100 dilution, staining GAMT in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry.
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab126736 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab126736.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up