Overview

  • Product name
  • Description
    Mouse polyclonal to GAS 6
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-678 of Human GAS 6

  • Positive control
    • 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 80 kDa).
    Detection Antibody Pair.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
    • Tissue specificity
      Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen.
    • Sequence similarities
      Contains 4 EGF-like domains.
      Contains 1 Gla (gamma-carboxy-glutamate) domain.
      Contains 2 laminin G-like domains.
    • Post-translational
      modifications
      Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
      Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • AXL receptor tyrosine kinase ligand antibody
      • AXL stimulatory factor antibody
      • AXLLG antibody
      • AXS F antibody
      • AXSF antibody
      • DKFZp666G247 antibody
      • FLJ34709 antibody
      • Gas 6 antibody
      • GAS-6 antibody
      • Gas6 antibody
      • GAS6_HUMAN antibody
      • Growth arrest specific 6 antibody
      • Growth arrest-specific protein 6 antibody
      • Growth-arrest-specific protein 6 antibody
      • Growth-arrest-specific protein 6 precursor antibody
      see all

    Images

    • All lanes : Anti-GAS 6 antibody (ab67099) at 1/500 dilution

      Lane 1 : GAS 6 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg/ml per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 80 kDa
      Observed band size : 75 kDa (why is the actual band size different from the predicted?)

    References

    ab67099 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab67099.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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