Overview

  • Product nameAnti-Gasdermin like antibody
    See all Gasdermin like primary antibodies
  • Description
    Rabbit polyclonal to Gasdermin like
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 21-194 of Human Gasdermin like (AAH25682).

  • Positive control
    • HeLa whole cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab103980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 47 kDa.

Target

  • FunctionThe N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown.
  • Tissue specificityIn the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.
  • Sequence similaritiesBelongs to the gasdermin family.
  • DomainIntramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.
  • Cellular localizationCytoplasm. Cytoplasm, cytosol. Cell membrane. Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.
  • Information by UniProt
  • Database links
  • FormThere are 5 isoforms produced by alternative splicing.
  • Alternative names
    • 123 antibody
    • 156 antibody
    • Gasdermin B antibody
    • Gasdermin like protein antibody
    • Gasdermin-B antibody
    • Gasdermin-like protein antibody
    • GSDMB antibody
    • GSDMB_HUMAN antibody
    • GSDML antibody
    • PP4052 antibody
    • PRO2521 antibody
    see all

Anti-Gasdermin like antibody images

  • Anti-Gasdermin like antibody (ab103980) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 47 kDa

References for Anti-Gasdermin like antibody (ab103980)

ab103980 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"