Overview

  • Product nameAnti-Gastrin antibody
    See all Gastrin primary antibodies
  • Description
    Rabbit polyclonal to Gastrin
  • SpecificityThis antibody detects Gastrin
  • Tested applicationsSuitable for: Dot blot, IHC-Fr, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: all Mammals
  • Immunogen

    Human gastrin 17 conjugated to BSA.

  • Positive control
    • Antrum.
  • General notesGastrin secreting cells are numerous in the antrum and few are found in the proximal duodenum.

Properties

Applications

Our Abpromise guarantee covers the use of ab8492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
WB Use at an assay dependent concentration.

Target

  • FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • Sequence similaritiesBelongs to the gastrin/cholecystokinin family.
  • Post-translational
    modifications
    Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Component II antibody
    • G14 antibody
    • G17 antibody
    • G34 antibody
    • G52 antibody
    • G6 antibody
    • GAS antibody
    • Gast antibody
    • GAST_HUMAN antibody
    • Gastrin antibody
    • Gastrin component I antibody
    • Gastrin component II antibody
    • Gastrin component III antibody
    • Gastrin precursor antibody
    • Gastrin-14 antibody
    • Gastrin-17 antibody
    • Gastrin-34 antibody
    • Gastrin-52 antibody
    • Gastrin-6 antibody
    • Gastrin-71 antibody
    see all

References for Anti-Gastrin antibody (ab8492)

This product has been referenced in:
  • Gonzalez-Coto AF  et al. Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea. Invest Ophthalmol Vis Sci 55:1965-75 (2014). Mouse . Read more (PubMed: 24576871) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. I have contacted the originator of the product but unfortunately the information about the immunogen sequence and the location of the antigen is unknown. I am sorry that we can not be of any further help.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"