Overview

  • Product nameAnti-Gastrin antibody (Biotin)
    See all Gastrin primary antibodies
  • Description
    Rabbit polyclonal to Gastrin (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: ELISA, IP, RIAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Sheep, Goat, Horse, Guinea pig, Cow, Cat, Dog, Pig, Rhesus monkey
  • Immunogen

    Synthetic peptide: QGPWLEEEEEAYGWMDF-NH2 conjugated to KLH via carboxyl group, corresponding to amino acids 76-92 of Human Gastrin.

Properties

Applications

Our Abpromise guarantee covers the use of ab48283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

Target

  • FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • Sequence similaritiesBelongs to the gastrin/cholecystokinin family.
  • Post-translational
    modifications
    Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Component II antibody
    • G14 antibody
    • G17 antibody
    • G34 antibody
    • G52 antibody
    • G6 antibody
    • GAS antibody
    • Gast antibody
    • GAST_HUMAN antibody
    • Gastrin antibody
    • Gastrin component I antibody
    • Gastrin component II antibody
    • Gastrin component III antibody
    • Gastrin precursor antibody
    • Gastrin-14 antibody
    • Gastrin-17 antibody
    • Gastrin-34 antibody
    • Gastrin-52 antibody
    • Gastrin-6 antibody
    • Gastrin-71 antibody
    see all

References for Anti-Gastrin antibody (Biotin) (ab48283)

ab48283 has not yet been referenced specifically in any publications.

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