General notesab94325 is a 293T cell transfected lysate in which Human GATA3 has been transiently over-expressed using a pCMV-GATA3 plasmid. The lysate is provided in 1 x Sample Buffer. Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundDisease: Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.
Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.
Similarity: Contains 2 GATA-type zinc fingers.
Tissue specificity: T-cells and endothelial cells.