Overview

  • Product nameAnti-GATM antibody
    See all GATM primary antibodies
  • Description
    Rabbit polyclonal to GATM
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the N terminal region of Human GATM (NP_001473.1).

  • Positive control
    • K562 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab107500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 48 kDa.

Target

  • FunctionCatalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
  • Tissue specificityExpressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues.
  • PathwayAmine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.
  • Involvement in diseaseDefects in GATM are the cause of arginine:glycine amidinotransferase deficiency (AGAT deficiency) [MIM:612718]. AGAT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, and severe depletion of creatine/phosphocreatine in the brain.
  • Sequence similaritiesBelongs to the amidinotransferase family.
  • DomainOne chain folds into a compact single domain composed of repeating units, five beta-beta-alpha-beta modules, which surround the central active site.
  • Cellular localizationMitochondrion inner membrane. Cytoplasm. The mitochondrial form is found in the intermembrane space probably attached to the outer side of the inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AGAT antibody
    • AT antibody
    • GATM antibody
    • GATM_HUMAN antibody
    • Glycine amidinotransferase antibody
    • Glycine amidinotransferase, mitochondrial antibody
    • L-arginine:glycine amidinotransferase antibody
    • mitochondrial antibody
    • Transamidinase antibody
    see all

Anti-GATM antibody images

  • Anti-GATM antibody (ab107500) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 48 kDa

References for Anti-GATM antibody (ab107500)

ab107500 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"