Overview

  • Product name
    Anti-GBA3 antibody
  • Description
    Rabbit polyclonal to GBA3
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-139 of Human GBA3 (Q9H227)

  • Positive control
    • 293T, A431 or Jurkat lysate, Human colon carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab154897 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 54 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Alternatively Tris-EDTA buffer (pH8.0) may be used.

Target

  • Function
    Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
  • Tissue specificity
    Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas.
  • Sequence similarities
    Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
  • Post-translational
    modifications
    The N-terminus is blocked.
  • Cellular localization
    Cytoplasm > cytosol.
  • Information by UniProt
  • Database links
  • Alternative names
    • CBG antibody
    • CBGL1 antibody
    • Cytosolic beta glucosidase antibody
    • Cytosolic beta glucosidase like protein 1 antibody
    • Cytosolic beta-glucosidase antibody
    • Cytosolic beta-glucosidase-like protein 1 antibody
    • GBA3 antibody
    • GBA3_HUMAN antibody
    • GLUC antibody
    • Glucosidase beta acid 3 antibody
    • Klotho related protein antibody
    • KLRP antibody
    see all

Images

  • Anti-GBA3 antibody (ab154897) at 1/500 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size: 54 kDa



    10% SDS PAGE
  • Immunohistochemical analysis of paraffin embedded Human colon carcinoma tissue labeling GBA3 with ab154897 at a 1/250 dilution.

References

ab154897 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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