Anti-GCAP1 antibody - Carboxyterminal end (ab38593)


  • Product nameAnti-GCAP1 antibody - Carboxyterminal end
    See all GCAP1 primary antibodies
  • Description
    Rabbit polyclonal to GCAP1 - Carboxyterminal end
  • Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (10-30 aa in length) from the last C-terminal 50 amino acids of human GCAP1, conjugated to KLH

  • Positive control
    • Y79 cell lysate; human breast carcinoma tissue



Our Abpromise guarantee covers the use of ab38593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 23 kDa (predicted molecular weight: 23 kDa).
IHC-P Use at an assay dependent concentration.


  • FunctionStimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
  • Tissue specificityRetina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.
  • Involvement in diseaseDefects in GUCA1A are the cause of cone dystrophy type 3 (COD3) [MIM:602093]. COD3 is an autosomal dominant cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies, in which some loss of peripheral vision also occurs.
  • Sequence similaritiesContains 4 EF-hand domains.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • COD3 antibody
    • GCAP 1 antibody
    • GCAP antibody
    • Guanylate Cyclase Activating Protein Photoreceptor 1 antibody
    • Guanylate cyclase activator 1A antibody
    • Guanylin 1 antibody
    • guanylyl cyclase activating protein 1 antibody
    • Guanylyl cyclase-activating protein 1 antibody
    • GUC1A_HUMAN antibody
    • GUCA antibody
    • GUCA1 antibody
    • GUCA1A antibody
    see all

Anti-GCAP1 antibody - Carboxyterminal end images

  • Anti-GCAP1 antibody - Carboxyterminal end (ab38593) at 1/100 dilution + Y79 cell lysate

    Predicted band size : 23 kDa
    Observed band size : 23 kDa
  • Formalin-fixed paraffin-embedded human breast carcinoma tissue reacted with ab38593, peroxidase-conjugated to the secondary antibody, followed by AEC staining.

References for Anti-GCAP1 antibody - Carboxyterminal end (ab38593)

ab38593 has not yet been referenced specifically in any publications.

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