Overview

  • Product name
  • Description
    Goat polyclonal to GCC2
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Horse, Macaque monkey, Common marmoset
  • Immunogen

    Synthetic peptide (

    C-QKLTNKNNKIED

    ) corresponding to internal sequence amino acids 1174-1185 of Human GCC2 (NP_852118.1).

  • Positive control
    • Human Small Intestine, Kidney and Spleen tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab113967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/16000.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • Function
    Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 GRIP domain.
  • Domain
    Extended rod-like protein with coiled-coil domains.
  • Cellular localization
    Cytoplasm. Golgi apparatus > trans-Golgi network membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 185 kDa Golgi coiled-coil protein antibody
    • CLL-associated antigen KW-11 antibody
    • CTCL tumor antigen se1-1 antibody
    • GCC protein, 185 kD antibody
    • GCC185 antibody
    • GCC2 antibody
    • GCC2_HUMAN antibody
    • Golgi coiled coil protein GCC185 antibody
    • GRIP and coiled coil domain containing 2 antibody
    • GRIP and coiled-coil domain-containing protein 2 antibody
    • KIAA0336 antibody
    • OTTHUMP00000217161 antibody
    • Ran-binding protein 2-like 4 antibody
    • RanBP2L4 antibody
    • REN53 antibody
    • Renal carcinoma antigen NY-REN-53 antibody
    see all

Images

  • ab113967 at 3.75 µg/ml staining GCC2 in Formalin-Fixed, Paraffin-Embedded Human Small Intestine tissue by Immunohistochemistry.
  • ab113967 at 3.75 µg/ml staining GCC2 in Formalin-Fixed, Paraffin-Embedded Human Kidney tissue by Immunohistochemistry.
  • ab113967 at 3.75 µg/ml staining GCC2 in Formalin-Fixed, Paraffin-Embedded Human Spleen tissue by Immunohistochemistry.

References

ab113967 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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