Overview

  • Product nameAnti-GCDH antibody
    See all GCDH primary antibodies
  • Description
    Rabbit polyclonal to GCDH
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-438 of Human GCDH (NP_000150.1).

  • Positive control
    • Human kidney tissue lysate; GCDH transfected 293T cell line lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab103415 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 48 kDa.

Target

  • FunctionCatalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
  • Tissue specificityIsoform 1 and isoform 2 are expressed in fibroblasts and liver.
  • PathwayAmino-acid metabolism; lysine degradation.
    Amino-acid metabolism; tryptophan metabolism.
  • Involvement in diseaseDefects in GCDH are the cause of glutaric aciduria type 1 (GA1) [MIM:231670]. GA1 is an autosomal recessive metabolic disorder characterized by progressive dystonia and athetosis due to gliosis and neuronal loss in the basal ganglia.
  • Sequence similaritiesBelongs to the acyl-CoA dehydrogenase family.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACAD5 antibody
    • EC 1.3.99.7 antibody
    • GCD antibody
    • Gcdh antibody
    • GCDH_HUMAN antibody
    • Glutaryl CoA dehydrogenase antibody
    • Glutaryl CoA dehydrogenase, mitochondrial antibody
    • Glutaryl Coenzyme A dehydrogenase antibody
    • Glutaryl-CoA dehydrogenase antibody
    • mitochondrial antibody
    • MS781 antibody
    see all

Anti-GCDH antibody images

  • Anti-GCDH antibody (ab103415) at 5 µg/ml + Human kidney tissue lysate at 50 µg

    Predicted band size : 48 kDa
  • All lanes : Anti-GCDH antibody (ab103415) at 5 µg/ml

    Lane 1 : GCDH transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 48 kDa

References for Anti-GCDH antibody (ab103415)

ab103415 has not yet been referenced specifically in any publications.

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