Overview

  • Product nameAnti-GCDH antibody
    See all GCDH primary antibodies
  • Description
    Rabbit polyclonal to GCDH
  • Tested applicationsSuitable for: ICC/IF, IP, WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from the N-terminal domain of human GCDH

Properties

Applications

Our Abpromise guarantee covers the use of ab75324 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 21163940
IP Use at an assay dependent concentration. PubMed: 21163940
WB 1/500 - 1/2000. Predicted molecular weight: 48 kDa.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Target

  • FunctionCatalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
  • Tissue specificityIsoform 1 and isoform 2 are expressed in fibroblasts and liver.
  • PathwayAmino-acid metabolism; lysine degradation.
    Amino-acid metabolism; tryptophan metabolism.
  • Involvement in diseaseDefects in GCDH are the cause of glutaric aciduria type 1 (GA1) [MIM:231670]. GA1 is an autosomal recessive metabolic disorder characterized by progressive dystonia and athetosis due to gliosis and neuronal loss in the basal ganglia.
  • Sequence similaritiesBelongs to the acyl-CoA dehydrogenase family.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACAD5 antibody
    • EC 1.3.99.7 antibody
    • GCD antibody
    • Gcdh antibody
    • GCDH_HUMAN antibody
    • Glutaryl CoA dehydrogenase antibody
    • Glutaryl CoA dehydrogenase, mitochondrial antibody
    • Glutaryl Coenzyme A dehydrogenase antibody
    • Glutaryl-CoA dehydrogenase antibody
    • mitochondrial antibody
    • MS781 antibody
    see all

References for Anti-GCDH antibody (ab75324)

This product has been referenced in:
  • Soler-López M  et al. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. Genome Res 21:364-76 (2011). WB, ICC/IF, IP ; Human . Read more (PubMed: 21163940) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"