Overview

  • Product name
    Anti-GCHFR antibody
  • Description
    Rabbit polyclonal to GCHFR
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide derived from an internal sequence of Human GCHFR.

  • Positive control
    • Human colon carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab110161 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
  • Tissue specificity
    In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
  • Sequence similarities
    Belongs to the GFRP family.
  • Cellular localization
    Nucleus. Nucleus membrane. Cytoplasm > cytosol.
  • Information by UniProt
  • Database links
  • Alternative names
    • GCHFR antibody
    • GFRP antibody
    • GFRP_HUMAN antibody
    • GTP cyclohydrolase 1 feedback regulatory protein antibody
    • GTP cyclohydrolase I feedback regulator antibody
    • GTP cyclohydrolase I feedback regulatory protein antibody
    • HsT16933 antibody
    • MGC138467 antibody
    • MGC138469 antibody
    • p35 antibody
    see all

Images

  • ab110161, at a 1/50 dilution, staining GCHFR in paraffin embedded Human colon carcinoma tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of the immunizing peptide.

References

ab110161 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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