Anti-GCN2 (phospho T899) antibody [EPR2320Y] (ab75836)

Publishing research using ab75836? Please let us know so that we can cite the reference in this datasheet.

ab75836 has been referenced in 19 publications.

  • Cormerais Y  et al. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem 293:2877-2887 (2018). PubMed: 29326164
  • Kitazawa S  et al. Cancer with low cathepsin D levels is susceptible to vacuolar (H+)-ATPase inhibition. Cancer Sci 108:1185-1193 (2017). PubMed: 28317223
  • Okada A  et al. D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation. Sci Rep 7:11168 (2017). PubMed: 28894140
  • Zubovych IO  et al. A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. Mol Cancer Ther 15:23-36 (2016). PubMed: 26668189
  • Xia X  et al. Arginine Supplementation Recovered the IFN-?-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2a Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells. Mol Cells 39:410-7 (2016). WB . PubMed: 27025389
  • Bretin A  et al. Activation of the EIF2AK4-EIF2A/eIF2a-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection. Autophagy 12:770-83 (2016). WB . PubMed: 26986695
  • Sbodio JI  et al. Transcriptional control of amino acid homeostasis is disrupted in Huntington's disease. Proc Natl Acad Sci U S A 113:8843-8 (2016). PubMed: 27436896
  • Yu X & Long YC Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis. Sci Rep 6:30033 (2016). PubMed: 27425006
  • Cormerais Y  et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res 76:4481-92 (2016). WB ; Human . PubMed: 27302165
  • Chaveroux C  et al. In vivo imaging of the spatiotemporal activity of the eIF2a-ATF4 signaling pathway: Insights into stress and related disorders. Sci Signal 8:rs5 (2015). WB ; Mouse . PubMed: 25921292
  • Wengrod J  et al. Phosphorylation of eIF2a triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma. Sci Signal 8:ra27 (2015). WB ; Human . PubMed: 25759478
  • Roffé M  et al. IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2a kinase GCN2 in the modulation of neurite outgrowth. J Biol Chem 288:10860-9 (2013). WB ; Mouse . PubMed: 23447528
  • Tattoli I  et al. Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J 32:3066-78 (2013). PubMed: 24162724
  • Morotomi-Yano K  et al. Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2a phosphorylation and 4E-BP1 dephosphorylation. Exp Cell Res 318:1733-44 (2012). WB . PubMed: 22652449
  • Anderson BR  et al. Nucleofection induces transient eIF2a phosphorylation by GCN2 and PERK. Gene Ther : (2012). WB . PubMed: 22301437
  • Tattoli I  et al. The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole. Biol Open 1:1215-25 (2012). WB . PubMed: 23259056
  • Maddalo D  et al. A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death. PLoS One 7:e45690 (2012). PubMed: 23049684
  • Tattoli I  et al. Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe 11:563-75 (2012). PubMed: 22704617
  • Cai Q & Brooks HL Phosphorylation of eIF2a via the general control kinase, GCN2, modulates the ability of renal medullary cells to survive high urea stress. Am J Physiol Renal Physiol 301:F1202-7 (2011). WB ; Mouse . PubMed: 21880833


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