Overview

  • Product name
    Anti-GDF1 antibody - N-terminal
    See all GDF1 primary antibodies
  • Description
    Rabbit polyclonal to GDF1 - N-terminal
  • Host species
    Rabbit
  • Specificity
    ab189950 is predicted to not cross-react with any other members of the growth differentiation factor family.
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide within Human GDF1 (N terminal). The exact sequence is proprietary. (16 amino acid peptide from N terminal).
    Database link: P27539

  • Positive control
    • Human small intestine and lung tissues; Rat lung cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab189950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 39 kDa.
IHC-P Use a concentration of 5 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.

Target

  • Function
    May mediate cell differentiation events during embryonic development.
  • Tissue specificity
    Expressed in the brain.
  • Involvement in disease
    Defects in GDF1 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle.
    Defects in GDF1 are the cause of transposition of the great arteries dextro-looped type 3 (DTGA3) [MIM:613854]. A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries.
    Defects in GDF1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
  • Sequence similarities
    Belongs to the TGF-beta family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • DORV antibody
    • DTGA3 antibody
    • Embryonic growth/differentiation factor 1 antibody
    • GDF 1 antibody
    • GDF-1 antibody
    • GDF1 antibody
    • GDF1_HUMAN antibody
    • Growth differentiation factor 1 antibody
    see all

Images

  • Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human small intestine tissue labeling GDF1 with ab189950 at 5µg/ml.

  • Immunohistochemistry analysis of Human lung tissue labeling GDF1 with ab189950 at 20µg/ml.

  • Lane 1 : Anti-GDF1 antibody - N-terminal (ab189950) at 1 µg/ml
    Lane 2 : Anti-GDF1 antibody - N-terminal (ab189950) at 2 µg/ml

    All lanes : Rat lung cell lysate

    Predicted band size: 39 kDa

  • Immunofluorescence analysis of Human lung tissue labeling GDF1 with ab189950 at 20 µg/ml.

References

ab189950 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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